T&E - Analítica






POLYMORPHISM

 

ABOUT POLYMORPHISM

 

Polymorphism comes from the Greek language: poly = many and morph. = Form that defines the property of the chemical compounds to crystallize into several generically distinct forms.

 

The polymorphism is a fundamental knowledge for the study of the absorption of the pharmaceutical active (IFA), which can cause deviations of quality and influence the performance of the drugs.

 

Therefore, the understanding of the polymorphism opens a field of possibilities to be explored in the pharmaceutical area.

 

Crystalline polymorphism can be conceptualized as the ability of a compound to exist in the solid state in more than one crystalline form.

 

Considering the formation of a crystalline state, there is also the possibility of solid Amorphous and Solvates.

 

Amorphous Solids: while crystals are characterized by the three-dimensional spatial repetition of the atoms or molecules that constitute them, the amorphous forms have atoms or molecules randomly distributed as in a liquid.

 

Solvates: an adduct is the result of the direct combination of two or more distinct molecules resulting in crystalline product whose structure is formed by all components but with their individual integrity preserved. When solvent molecules are part of the crystalline reticulum, these adducts are termed solvates. Solvates whose solvent of crystallization is water are called hydrates. (Lachman et al., 2001). Solvates can also be called pseudopolymorphs (Spong et al., 2004; Gavezzotti, 2007). It should be noted that amorphous can not be considered polymorphic.

 

 

The T&E Center is prepared to evaluate its IFA in its different analytical nuances.

 

ANALYTICAL TECHNIQUES

The search for determination of the polymorphism begins with a bibliographical research on the main polymorphs present. After the bibliographic research, tests are performed on the sample in order to obtain satisfactory analytical condition in order to define the type of polymorph.

 

The T&E Analytical Center has the following main polymorphic search techniques.

·         DSC / ATD - Differential Exploration Calorimetry;

·         High resolution microscopy with light polarizer;

·         Infrared Fourier Transform;

·         Saturation solubility: solvents and temperature;

 

 

Other Techniques

 

After evaluating our team and depending on the analysis by the techniques mentioned, other techniques may complement, if necessary, such as:

 

·         Diffraction X, TG / DTG, H and C NMR (techniques outsourced by T&E)

·         Profiles of Dissolution, among others.

 

 

 

Other solutions may occur during the technical exchange and thus, solve the problem of your company.